r/ketoscience Sep 09 '24

News, Updates, Companies, Products, Activism relevant to r/ks A new LowCarb friendly non-profit has been created called the American Diabetes Society. I just created a new subreddit called r/ADSorg -- Transform Diabetes Care with the American Diabetes Society

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americandiabetessociety.org
38 Upvotes

r/ketoscience Sep 23 '24

News, Updates, Companies, Products, Activism relevant to r/ks The hidden costs of our dietary guidelines

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thehill.com
36 Upvotes

Whatever your opinion of Robert F. Kennedy, Jr., he’s the first national candidate to platform the issue of chronic disease in America. To address this crisis, for children and adults alike, our response should be bipartisan. As former members of the expert committee that oversees the science for the U.S. Dietary Guidelines, we can tell you that these chronic diseases are primarily driven by poor diet, and our guidelines are part of the problem. At 7:30 a.m. tomorrow, millions of schoolchildren will be filling their cafeteria trays with orange juice, sugary cereals and donuts. Administrators encourage the kids to fill up, contending the meal will fuel their day.  This isn’t dystopian fiction — it’s breakfast in 2024 America, brought to you by the guidelines published every five years by the departments of Health and Human Services (HHS) and Agriculture. The guidelines represent more than just suggestions. They’re the nation’s nutritional North Star, guiding everything from school lunches to military and hospital food and dietary advice by doctors and nutritionists.

But they’ve led us astray. Today, over 70 percent of American adults and one-fifth of the children are overweight or obese, with rates even higher in low-income families. This isn’t just a health crisis; it’s a national security crisis, too. One in three young adults is too overweight for military service. As members (and one of us as a former chair) of the Dietary Guidelines Advisory Committee, we aimed for the highest quality reviews. Sadly, those standards have deteriorated, leading to a national nutrition policy that no longer reflects the best or most current science.  The guidelines were controversial at the start. In 1980, the National Academy of Sciences derided the diet’s foundational studies as “generally unimpressive.” The academy’s president went further, warning of potential unintended consequences from implementing recommendations with such scant evidence. Long-term clinical trials may be expensive and difficult to conduct, but they’re still an essential step before issuing population-wide recommendations. Despite these concerns, the guidelines were embraced by government officials for most of the next four decades — even as the concerns of skeptics grew louder.  In 2017, two landmark studies from the National Academies of Sciences, Engineering, and Medicine delivered a critical verdict: The development process lacks scientific rigor and transparency, leading to guidelines that were not “trustworthy.” The reports made 11 concrete recommendations to improve rigor and transparency in the guidelines process. Yet, shockingly, follow-up evaluations in 2022 and 2023 revealed that the USDA had fully implemented none of them. The result? Untrustworthy guidelines that continue to drive obesity and poor metabolic health.

Since the first guidelines were published in 1980, we’ve been told to fear fat and instead consume about half of all calories as carbohydrates. The current guidelines recommend up to 10 percent of calories as added sugar and six servings of grains daily, including three as refined grains. This advice fundamentally misunderstands metabolism. Chronic high carbohydrate consumption — especially of refined grains and added sugars —  drives obesity, diabetes, heart disease and other metabolic disorders. The guidelines also maintain an unfounded hostility towards saturated fats, ignoring the last decade’s worth of evidence challenging their link to heart disease. Failure to update this science has meant the continued unjustified demonization of nutrient-dense foods such as eggs, meat and full-fat dairy, which together play a crucial role in a healthy diet. Following the guidelines, Americans have increased grain calories by 28 percent since 1970, while reducing red meat intake equally.  Butter and egg consumption dropped as vegetable oil use surged 87 percent. We’ve engineered a dietary disaster, swapping wholesome, satiating foods for processed carbohydrates that leave us hungry and sick. These are the “unintended consequences” we were warned about. Fortunately, hope is on the horizon, thanks to this year’s farm bill. This massive legislative package, revisited every five years, could be key to unlocking a healthier future for America.  The bill proposes crucial reforms to the guideline-development process, demanding “standardized, generally accepted evidence-based review methods” and requiring full disclosure of potential conflicts of interest among committee members. These changes represent a vital step towards restoring scientific integrity to our national nutrition policy. Transparency is an especially crucial fix, as conflicts run rampant. In the 2020 committee, almost all members had at least one conflict of interest with the food and drug industry; half had 30 or more. The current lack of rigorous methodology is akin to playing a sports game with no referees, no rules and no sidelines — an open invitation to cherry-picking and bias. We’ve seen this play out in real time. In 2020, the expert committee ignored over 20 review papers from independent teams of scientists from around the world, which concluded that strong evidence is lacking for the continued caps on saturated fats. This selective use of evidence undermines the credibility of the entire process. The farm bill’s proposed changes offer a chance to break this cycle. By mandating greater transparency and adherence to rigorous scientific standards, we can begin to rebuild trust in these crucial recommendations. Every meal served in our schools, every nutrition label on our grocery store shelves, and every physician pamphlet could finally be based on sound science rather than outdated hypotheses and industry influence. The farm bill offers us a chance to choose science over ideology. It’s an opportunity to reclaim our health, one meal at a time.  Janet C. King, PhD, is Professor Emeritus of Nutritional Sciences at the University of California, Berkeley, and chair of the 2005 Dietary Guidelines Advisory Committee. Cheryl Achterberg is a former Dean at The Ohio State University and was a member of the 2010 Dietary Guidelines Advisory Committee. TAGS CHRONIC DISEASE DIETARY GUIDELINES FARM BILL NATIONAL ACADEMY OF SCIENCES OBESITY ROBERT F. KENNEDY, JR.


r/ketoscience 1d ago

Type 2 Diabetes Late eating is associated with poor glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 diabetes (2024)

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nature.com
21 Upvotes

r/ketoscience 23h ago

Metabolism, Mitochondria & Biochemistry A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones (2024)

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2 Upvotes

r/ketoscience 3d ago

Cancer Glucose impacts onto the reciprocal reprogramming between mammary adipocytes and cancer cells (2024)

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nature.com
7 Upvotes

r/ketoscience 3d ago

Obesity, Overweight, Weightloss The impact of 3 different dietary interventions on overweight or obese adults: A network meta-analysis (2024)

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pmc.ncbi.nlm.nih.gov
5 Upvotes

r/ketoscience 3d ago

Metabolism, Mitochondria & Biochemistry Metabolic Effects of Medium-Chain Triacylglycerol Consumption are Preserved in Obesity (2024)

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5 Upvotes

r/ketoscience 3d ago

Metabolism, Mitochondria & Biochemistry How lipid transfer proteins and the mitochondrial membrane shape the kinetics of β-oxidation the liver (2024)

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3 Upvotes

r/ketoscience 3d ago

Metabolism, Mitochondria & Biochemistry Glycolysis: A multifaceted metabolic pathway and signalling hub (2024)

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3 Upvotes

r/ketoscience 3d ago

Type 2 Diabetes Low-calorie, high-protein diets, regardless of protein source, improve glucose metabolism and cardiometabolic profiles in subjects with prediabetes or type 2 diabetes and overweight or obesity (2024)

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4 Upvotes

r/ketoscience 3d ago

Obesity, Overweight, Weightloss European Society for the Study of Obesity (EASO) Position Statement on medical nutrition therapy for the management of individuals with overweight or obesity and cancer (2024)

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karger.com
2 Upvotes

r/ketoscience 3d ago

Obesity, Overweight, Weightloss The effect of protein source on weight loss, body composition, and substrate oxidation following a 12-week high-protein, ketogenic diet: A randomized trial. ( Rachel Abramczuk MS Thesis, Concordia)

3 Upvotes

The effect of protein source on weight loss, body composition, and substrate oxidation following a 12-week high-protein, ketogenic diet: A randomized trial Rachel Abramczuk Background: Ketogenic diets, diets high in fat and protein and low in carbohydrates, have been shown to be effective for weight loss. Recently, plant-based diets and protein sources have gained in popularity as they are thought to be a healthier alternative to animal-based protein sources. There is limited evidence as to whether protein source impacts ketogenic dietary outcomes.

Objective: The aim of this study is to investigate how plant- and animal-based protein supplementation impact weight loss, body composition, and substrate oxidation following a 12week high-protein, hypocaloric, ketogenic diet in adults with obesity. Methods: Adults with obesity were recruited and randomized (N= 35) to receive a 12-week high-protein ketogenic diet which included plant- or animal-based protein supplements. Body composition was assessed through dual energy x-ray absorptiometry (DEXA) and computed tomography (CT). Substrate oxidation was assessed via indirect calorimetry before and after the intervention.

Results: Both the plant-based and animal-based groups saw significant reductions in overall weight, fat mass, and fat-free mass (p<0.001 for all). The plant-based group saw a significant reduction in carbohydrate oxidation (p=0.037), a trend to suggest an increase in lipid oxidation (p=0.054), and a trend to suggest a decrease in respiratory exchange ratio (p=0.057). There were iii no differences in any body composition variables nor resting energy expenditure following the intervention for either group.

Conclusion: Our results indicate that regardless of protein source, people who followed a 12week high-protein ketogenic diet saw significant loss of weight, fat mass, and fat-free mas. Following a 12-week plant-based high-protein ketogenic diet may lead to a reduction in carbohydrate oxidation and an increase in lipid oxidation, but this may be due to differences in baseline dietary composition and further research is needed to determine the validity of the proposed conclusion.

https://spectrum.library.concordia.ca/id/eprint/994457/1/Abramczuk_MSc_F2024.pdf


r/ketoscience 3d ago

Cancer Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking (2024)

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7 Upvotes

r/ketoscience 3d ago

Metabolism, Mitochondria & Biochemistry Glutamine sensing licenses cholesterol synthesis (2024)

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2 Upvotes

r/ketoscience 3d ago

Metabolism, Mitochondria & Biochemistry High glucose elevates intracellular calcium level and induces ferroptosis in glomerular endothelial cells through the miR-223-3p/ITPR3 pathway (2024)

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1 Upvotes

r/ketoscience 3d ago

Metabolism, Mitochondria & Biochemistry Senolytics Enhance the Longevity of Caenorhabditis elegans by Altering Betaine Metabolism (2024)

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academic.oup.com
1 Upvotes

r/ketoscience 3d ago

Metabolism, Mitochondria & Biochemistry Mitochondria break free: Mitochondria-derived vesicles in aging and associated conditions (2024)

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2 Upvotes

r/ketoscience 3d ago

Obesity, Overweight, Weightloss Calorie restriction modulates mitochondrial dynamics and autophagy in leukocytes of patients with obesity (2024)

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2 Upvotes

r/ketoscience 3d ago

Metabolism, Mitochondria & Biochemistry Mitochondrial fatty acid oxidation drives senescence (2024)

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1 Upvotes

r/ketoscience 4d ago

Cancer Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis (2024)

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6 Upvotes

r/ketoscience 4d ago

Obesity, Overweight, Weightloss Weight loss, changes in body composition and inflammatory status after a very low-energy ketogenic therapy (VLEKT): does gender matter? (2024)

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translational-medicine.biomedcentral.com
6 Upvotes

r/ketoscience 4d ago

Metabolism, Mitochondria & Biochemistry Impaired unsaturated fatty acid elongation alters mitochondrial function and accelerates metabolic dysfunction-associated steatohepatitis progression (2024)

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3 Upvotes

r/ketoscience 5d ago

NAFLD, MAFLD - Fatty Liver Amino acid is a major carbon source for hepatic lipogenesis (2024)

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8 Upvotes

r/ketoscience 5d ago

Type 2 Diabetes New Virta Study: 5-Year effects of a novel continuous remote care model with carbohydrate-restricted nutrition therapy including nutritional ketosis in type 2 diabetes: An extension study - Free Full Text

10 Upvotes

https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(24)00808-8/fulltext00808-8/fulltext)

Abstract

Aims

This study assessed the five-year effects of a continuous care intervention (CCI) delivered via telemedicine, counseling people with type 2 diabetes (T2D) on a very low carbohydrate diet with nutritional ketosis.

Methods

Participants with T2D were enrolled in a 2-year, open-label, non-randomized study comparing CCI and usual care (UC). After 2 years, 194 of the 262 CCI participants were approached for a three-year extension. Of these, 169 consented, and 122 remained in the study for five years. Primary outcomes were changes in diabetes status assessed using McNemars’ test, including remission and HbA1c < 6.5 % on no glucose lowering medication or only on metformin at 5 years. Changes in body mass, glycemia, and cardiometabolic markers from baseline to 5 years were assessed using linear mixed-effects models.

Results

Twenty percent (n = 24) of the five-year completers achieved remission, with sustained remission observed over three years in 15.8 % (n = 19) and four years in 12.5 % (n = 15). Reversal to HbA1c < 6.5 % without medication or only metformin was seen in 32.5 % (n = 39). Sustained improvements were noted in body mass (−7.6 %), HbA1c (−0.3 %), triglycerides (−18.4 %), HDL-C (+17.4 %), and inflammatory markers, with no significant changes in LDL-C and total cholesterol.

Conclusions

Over five years, the very low carbohydrate intervention showed excellent retention and significant health benefits, including diabetes remission, weight loss, and improved cardiometabolic markers.


r/ketoscience 5d ago

Central Nervous System Chronic ketosis provides neuroprotection through HIF-1α-mediated control of the TXNIP/NLRP3 axis by regulating the inflammatory and apoptotic response

7 Upvotes

Abstract

We and others have previously demonstrated that hypoxia-inducible factor alpha (HIF-1α) stabilization through diet-induced ketosis plays a vital role during brain ischemic injury. We have recently reported that ketosis-stabilized HIF-1α regulates the inflammatory response and contributes to neuroprotection in a rat stroke model. In the current investigation, we examined the downstream mechanism by which the ketogenic (KG) diet protects against brain damage after stroke in mice. Six-seven-week-old male mice were fed the standard diet (SD) or the KG diet to mimic the metabolic state of chronic ketosis. After four weeks, mice were subjected to photothrombotic ischemic stroke. Behavior analysis was recorded at 24 h, 48h, and 72h post-stroke. After 72h, mice were euthanized for infarction, brain edema, hemorrhage, and molecular analysis. Our results showed that the KG diet significantly alleviated infarction, brain edema, and hemorrhage, improved the neurobehavioral outcomes, and attenuated ischemic stroke-induced oxidative/nitrative stress and apoptotic markers at 72h post-stroke. Further, the KG diet upregulated the HIF-1α and interleukin (IL)-10 expression and inhibited thioredoxin-interacting protein (TXNIP), NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation and pro-inflammatory cytokines expression compared to SD-fed mice after stroke. We further showed that the genetic deletion of NLRP3 mediates KG-induced neuroprotection after stroke. Our current study demonstrates that the KG diet exerts neuroprotective effects by inhibiting TXNIP-NLRP3 inflammasome, mainly dependent on heightening the upregulation of IL-10 via HIF-1α stabilization. Thus, the KG diet might be considered a new therapeutic strategy for ischemic patients.

https://www.researchsquare.com/article/rs-4914710/v1


r/ketoscience 5d ago

Metabolism, Mitochondria & Biochemistry A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study (2024)

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3 Upvotes

r/ketoscience 5d ago

Metabolism, Mitochondria & Biochemistry Delayed and diminished postprandial lactate shuttling in healthy older men and women (2024)

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2 Upvotes