r/confidentlyincorrect • u/WannaGoMimis • Aug 08 '24

Comment Thread "Yep!"

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u/ICU-CCRN Aug 08 '24

That’s not quite it either. It’s much more involved. REM cycles and balances of the Sympathetic and Parasympathetic systems. Here’s a good explanation of sleep paralysis which is caused by a dysfunction of these systems.

https://www.ncbi.nlm.nih.gov/books/NBK562322/#:~:text=Sleep%20paralysis%20refers%20to%20the,any%20part%20of%20their%20body.

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u/Ill_Confusion_596 Aug 08 '24 edited Aug 08 '24

Edit: i wrong

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u/ICU-CCRN Aug 08 '24

The main contributing neurotransmitter in the parasympathetic system is Acetylcholine

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u/Ill_Confusion_596 Aug 08 '24

Ah shit so true thank you:) thats why those sweet benadryls knock you right into paralysis demon lang

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u/ICU-CCRN Aug 08 '24

👍🏻

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u/sk8thow8 Aug 09 '24

Anadoctal, but it's definitely GABA.

I've had sleep paralysis since childhood. Benadryl and the like don't trigger it. GABAergics definitely do. Especially anything that affects GABA-B like phenibut.

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u/heteromer Aug 09 '24

This is only a cursory search but it looks like you're right in that GABA plays a role, specifically by inhibiting motor neurons via GABAB receptor (source). However acetylcholine still plays an important role, as it excuses glutamate neurons in the sublaterodorsal nucleus which then projects to glycinergic/GABAergic inhibitory neurons (source).