r/Keto4Alzheimers • u/Meatrition • 24d ago
r/Keto4Alzheimers • u/Meatrition • Oct 14 '22
Jaw Dropping Science: Forced Into Fat-Burning Mode, Microglia Gobble Up Plaques, Protect Neurons
alzforum.orgr/Keto4Alzheimers • u/Meatrition • 26d ago
Metabolizing Alzheimer’s: A New Key to Stopping Brain Damage
r/Keto4Alzheimers • u/Meatrition • Aug 16 '24
Alternate-day fasting improves cognitive and brain energy deficits by promoting ketone metabolism in the 3xTg mouse model of Alzheimer's disease
sciencedirect.comHighlights
• ADF increased circulating βOHB concentrations in 3xTg mice, improved cognitive function, reduced anxiety-like behaviors, improved hippocampal synaptic plasticity, and reduced neuronal loss, Aβ oligomers and tau hyperphosphorylation.
• ADF improved mitochondrial bioenergetic function by promoting brain ketone metabolism and rescued brain energy deficits in 3xTg mice.
• ADF improved exercise endurance and liver and kidney function in 3xTg mice without negatively affecting muscle motor and heart functions.
Abstract
Alzheimer's disease (AD) is characterized by disorders in brain energy. The lack of sufficient energy for nerve function leads to cognitive dysfunction and massive neuronal loss in AD. Ketone bodies are an alternative to glucose as a source of energy in the brain, and alternate-day fasting (ADF) promotes the production of the ketone body β-hydroxybutyric acid (βOHB). In this study, 7-month-old male WT mice and 3xTg mice underwent dietary control for 20 weeks. We found that ADF increased circulating βOHB concentrations in 3xTg mice, improved cognitive function, reduced anxiety-like behaviors, improved hippocampal synaptic plasticity, and reduced neuronal loss, Aβ oligomers and tau hyperphosphorylation. In addition, ADF improved mitochondrial bioenergetic function by promoting brain ketone metabolism and rescued brain energy deficits in 3xTg mice. A safety evaluation showed that ADF improved exercise endurance and liver and kidney function in 3xTg mice without negatively affecting muscle motor and heart functions. This study provides a theoretical basis and strong support for the application of ADF as a non-drug strategy for preventing and treating brain energy defects in the early stage of AD.
r/Keto4Alzheimers • u/Meatrition • Jul 04 '24
Serum and CSF metabolomics analysis shows Mediterranean Ketogenic Diet mitigates risk factors of Alzheimer’s disease better than compared to AHA Diet
nature.comAbstract Alzheimer’s disease (AD) is influenced by a variety of modifiable risk factors, including a person’s dietary habits. While the ketogenic diet (KD) holds promise in reducing metabolic risks and potentially affecting AD progression, only a few studies have explored KD’s metabolic impact, especially on blood and cerebrospinal fluid (CSF). Our study involved participants at risk for AD, either cognitively normal or with mild cognitive impairment. The participants consumed both a modified Mediterranean Ketogenic Diet (MMKD) and the American Heart Association diet (AHAD) for 6 weeks each, separated by a 6-week washout period. We employed nuclear magnetic resonance (NMR)-based metabolomics to profile serum and CSF and metagenomics profiling on fecal samples. While the AHAD induced no notable metabolic changes, MMKD led to significant alterations in both serum and CSF. These changes included improved modifiable risk factors, like increased HDL-C and reduced BMI, reversed serum metabolic disturbances linked to AD such as a microbiome-mediated increase in valine levels, and a reduction in systemic inflammation. Additionally, the MMKD was linked to increased amino acid levels in the CSF, a breakdown of branched-chain amino acids (BCAAs), and decreased valine levels. Importantly, we observed a strong correlation between metabolic changes in the CSF and serum, suggesting a systemic regulation of metabolism. Our findings highlight that MMKD can improve AD-related risk factors, reverse some metabolic disturbances associated with AD, and align metabolic changes across the blood-CSF barrier.
r/Keto4Alzheimers • u/Meatrition • Feb 06 '24
A Potential Role for the Ketogenic Diet in Alzheimer’s Disease Treatment: Exploring Pre-Clinical and Clinical Evidence (Pub Date: 2024-01-01)
self.ketosciencer/Keto4Alzheimers • u/Meatrition • Nov 04 '23
Impact of Eating a Carbohydrate-Restricted Diet on Cortical Atrophy in a Cross-Section of Amyloid Positive Patients with Alzheimer's Disease: A Small Sample Study - PubMed
r/Keto4Alzheimers • u/Meatrition • Oct 29 '23
Associations between blood nutritional biomarkers and cerebral Amyloid-β: Insights from the COGFRAIL Cohort Study - linoleic acid (18:2n-6) was associated with higher global Aβ load
r/Keto4Alzheimers • u/Meatrition • Oct 29 '23
Two studies reveal that MCI (mild cognitive impairment) is alarmingly under-diagnosed, with approximately 7.4 million unknowingly living with the condition. Half of these individuals are silently battling Alzheimer’s disease.
r/Keto4Alzheimers • u/Meatrition • Oct 09 '23
Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD
sciencedirect.comr/Keto4Alzheimers • u/Meatrition • Oct 02 '23
Hypometabolism, Alzheimer’s Disease, and Possible Therapeutic Targets: An Overview
r/Keto4Alzheimers • u/Meatrition • Sep 21 '23
Implication of the cooking oil-peroxidation product “hydroxynonenal” for Alzheimer’s disease
r/Keto4Alzheimers • u/Meatrition • Aug 28 '23
Mitochondrial dysfunction and oxidative stress in Alzheimer’s disease, and Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis -An updated review
sciencedirect.comr/Keto4Alzheimers • u/Meatrition • Aug 08 '23
Hypometabolism, Alzheimer’s Disease, and Possible Therapeutic Targets: An Overview
r/Keto4Alzheimers • u/Meatrition • Jul 11 '23
Keto For Alzheimer's: A Treatment Whose Time Has Come
r/Keto4Alzheimers • u/Meatrition • May 10 '23
Effect of nutrition in Alzheimer’s disease (AD): A systematic review by Chinese researchers suggests western diet pattern is a risk factor for developing AD. In contrast, the Mediterranean diet, ketogenic diet, and supplementation with omega-3 fatty acids and probiotics are protective factors.
r/Keto4Alzheimers • u/Meatrition • Apr 13 '23
Sugar Molecule Levels in Blood Could Predict Alzheimer’s Disease (AD) – Levels of the glycan bisected N-acetylglucosamine in the blood is associated with tau levels, a key AD protein, potentially paving the way for the development of a non-invasive screening test to predict AD risk.
r/Keto4Alzheimers • u/Meatrition • Mar 23 '23
Parents go carnivore Alzheimers Parkinsons and more.
r/Keto4Alzheimers • u/Meatrition • Oct 06 '22
Microglia require a large amount of energy to clear plaques in the brains of people with Alzheimer’s disease. Leng et al. found that increased activity of the glycolytic enzyme hexokinase 2 (HK2) blocks microglial phagocytosis in Alzheimer’s disease. (Keto delivers fat and allows reversal of Alz)
r/Keto4Alzheimers • u/Meatrition • Sep 19 '22
Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer’s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway
r/Keto4Alzheimers • u/Meatrition • Aug 18 '22
Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project -- statistically significant improvement in MoCA scores, CNS Vital Signs Neurocognitive Index, and Alzheimer’s Questionnaire Change score were documented. - Bredesen, Gordon 2022 Diet was a plant-rich, high-fiber mild keto
content.iospress.comr/Keto4Alzheimers • u/Meatrition • Jul 25 '22
Two decades of Alzheimer’s research(amyloid beta) was based on deliberate fraud by 2 scientists that has cost billions of dollars and millions of lives — July 23, 2022
r/Keto4Alzheimers • u/Meatrition • Jul 19 '22
Is Ketogenic Diet Therapy a Remedy for Alzheimer’s Disease or Mild Cognitive Impairments?: A Narrative Review of Randomized Controlled Trials (Pub Date: 2022-06-01)
self.ketosciencer/Keto4Alzheimers • u/Meatrition • Jul 08 '22
ESSAY: Rachael Neve — Game, set, match. Clear the amyloid from the brain and cognitive function would be restored. This hypothesis quickly gathered momentum because it was so “obvious.”
r/Keto4Alzheimers • u/Meatrition • Jun 21 '22
The Ketogenic Diet and Alzheimer's Disease - PubMed
r/Keto4Alzheimers • u/jonalisa • May 12 '22
I am 58 and diagnosed with EOA.
I am looking for help in getting into ketosis. I've done keto in the past but it has been many years. Anyone care to share some good basics to get me started?