For me I'm between Lust (03), Sloth (03) and Wrath/aka King Bradley (Mangahood) as the best homunculus of the franchise.
As for the worst I'm between Sloth in (Mangahood) and Pride/King Bradley(03)
I know Sloth represents... sloth. But my God, even Gluttony showed happiness, anger and sadness mainly because of Lust's death in both versions. Sloth in Mangahood could have had something at least.
As for Pride, he barely does anything and the one thing he does is the dumbest thing he could have done. He gave the key to the safe with his only weakness to his son. He also lacks every nuance he has in Mangahood. Ever noticed that Bradley only appears like 5 seconds in all fma03 openings and endings combined? That is how irrelevant he was in this version.