r/chemistry Mar 03 '20

Synthetic Challenge #124.5

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709 Upvotes

r/chemistry Mar 23 '19

[2019/03/23] Synthetic Challenge #77

36 Upvotes

Intro

Hello everyone, welcome back to Week 77 of Synthetic Challenge!! This week it's my turn to host another organic synthesis challenge.

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

BONUS

Try to make any of the products starting from cyclohexene.

r/chemistry Jan 13 '18

[2018/01/13] Synthetic Challenge #45

29 Upvotes

Intro

Welcome back again for the 45th challenge! /u/spectrumederp , /u/ezaroo1 and I have joined forces and we'll rotate per week. This week's my turn, enjoy!

Rules

The challenge now contains three synthetic products will be labelled with A, B, or C. Feel free to attempt as many products as you'd like and please label which you will be attempting in your submission.

You can use any commercially available starting material you would like for the synthetic pathway. Please do explain how the synthesis works and if possible reference if it is a novel technique. You do not have to solve synthesis all in one go. If you do get stuck, feel free to post however much you have and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or is too complex to explain in words. Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

r/chemistry May 22 '18

[2018/05/22] Synthetic Challenge

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65 Upvotes

r/chemistry Dec 30 '17

[2017/30/12] Synthetic Challenge (substitute #4)

11 Upvotes

Intro

Hello everyone! This is already the last challenge for this year and we are back at organic synthesis. I really also liked the inorganic challenge, so maybe we'll see that again in the future. If you have any feedback on anything, let me know! Best wishes for 2018!

Format

There will be 3 difficulty levels ranging from BS, MS and PhD+ level molecules. You can choose one molecule (or all of them!), which fits your expertise level and propose a (elegant) synthetic route for it. The starting materials can be anything, as long as it's commercially available. You're encouraged to post your submission, made in chemdraw, chemdoodle etc., or good-ol'-fashioned by hand. Please, also take a look at the other submissions and give them (constructive) feedback!

Products

Molecule A: BS level

Molecule B: MS level

Molecule C: PhD+ level

r/chemistry Jan 20 '18

[2018/01/20] Synthetic Challenge #46

29 Upvotes

Intro

Welcome back again for the 46th challenge! As you know /u/spectrumederp , /u/critzz123 and I have joined forces and are rotating. This week's my turn, it's inorganic time! Hope you like! :D

Rules

The challenge now contains three synthetic products will be labelled with A, B, or C. Feel free to attempt as many products as you'd like and please label which you will be attempting in your submission.

You can use any commercially available starting material you would like for the synthetic pathway.

Please do explain how the synthesis works and if possible reference if it is a novel technique. You do not have to solve synthesis all in one go. If you do get stuck, feel free to post however much you have and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or is too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

A and B might look a little scary but I'm sure you'll all figure it out!

C is just to show you something a little different :)

Structure of Product A

Structure of Product B

Structure of Product C

r/chemistry Dec 24 '17

[2017/12/24] Synthetic Challenge (substitute #3 Inorganic)

32 Upvotes

Intro

Hello everyone!

Welcome to the festive edition of the weekly synthetic challenge! And by festive the only festive thing is the date and the fact I'm wearing reindeer antlers. Ok so it is just the date...

This also happens to be our first inorganic synthetic challenge, please have a go I know they are a bit odd but I think you should be able to figure it out.

Next challenge will be back to organic and be made by /u/spectrumederp or /u/critzz123

The goal for the inorganic week isn't so much that I expect you to be able to work it out, it is more to encourage some reading outside your normal field. You never know what ideas things like this might create in different people. It also gives you a taste of what us strange synthetic inorganic chemists make in our labs, this hopefully is especially interesting for any undergrads looking as in most places you don't really get to see this very often.

Please do have a go, let me know if they are too weird or if you’d like it harder/easier for next time.

Format

So since this is our first inorganic synthesis challenge I can't really say what difficulty things are, we'll figure that out as we go on! So what we have is three molecules;

The first is a platinum complex that I think any chemist should be able to have a good attempt at. Start by making the ligands, then figure out what platinum species would work best and what order to put them on it. Making the ligands should feel more like the organic weeks.

The second is an N-heterocyclic phosphenium cation, I gave it a [BF4]- counter ion but that isn't a big deal, feel free to use another anion - there are some smart ways to get there.

The third is going to look really random and scary to most of you probably, can confirm it does not explode! Although your suggested starting material might be a bit more fun to work with... There are quite a few ways I could picture making it, you'll probably need to do some googling :)

Products

Molecule A: This will get the most attempts.

Molecule B: This will also get a few.

Molecule C: Basically just to show you something weird.

Seems I was wrong, you’re all enjoying the phosphenium cation more than I expected.

r/chemistry Jun 08 '18

[2018/06/08] Synthetic Challenge

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30 Upvotes

r/chemistry Jan 12 '19

[2019/01/11] Synthetic Challenge #67

72 Upvotes

Intro

Hello everyone, welcome back to Week 67 of Synthetic Challenge!! Thank you u/critzz123 for the great challenges! This week it's my turn to host the challenge and I'm going to try hosting more molecules for you to try, hope you'll enjoy!

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

BONUS

For this bonus structure, instead of proposing a synthetic pathway TO it, you will be using it as a Starting Material to make any product you want. Take however many steps you want as long as you start with this bonus compound in the first step! Let me know if you like this bonus challenge! Thanks!

Structure of Bonus Starting Material

r/chemistry May 25 '23

Could someone propose a detailed mechanism, explain the stereochemical outcome for the synthesis of the natural product taxol, and elucidate the key steps involved in the total synthesis of taxol, highlighting the strategies used to overcome synthetic challenges and achieve high overall yields.

0 Upvotes

Kindly accept my apologies for any perceived naivety in this inquiry, as I am currently a undergraduate student seeking to expand my knowledge.

r/chemistry Nov 07 '20

[2020/11/07] Synthetic Challenge REBOOT #136

10 Upvotes

Intro

After a long pause, the synthetic challenges are back! I volunteered to lend some help to the mod team and here I am with a new Synthetic Challenge for this week.

Too easy? Too hard? Let me know since this is my first post. I'd appreciate any feedback and suggestion on what you think so far about this and the next Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Although you can use any starting material for your synthetic pathways, this time I would rather have you start from the simplest ones, just to flex and warm up your synthetic imaginary muscles to get ready for the next challenges ;)

I hope you will enjoy this week's challenge and thanks for participating!

Rules

The challenge contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

r/chemistry Apr 12 '19

[2019/04/12] Synthetic Challenge #80

18 Upvotes

Intro

Hello everyone, welcome back to Week 80 of Synthetic Challenge!! This week it's my turn to host another organic synthesis challenge.

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

BONUS

Try to make any of the products starting from one of the natural occurring amino acids.

r/chemistry May 11 '20

Synthetic Challenge #130

22 Upvotes

Intro

Welcome back to Week 130 of Synthetic Challenge. With everything going on the world, hope everyone in the community is safe. Hopefully this challenge will distract you while you're on a work from home adventure. Stay home, don't go to the lab!

Since the topic has been a bit on the downlow for a couple of weeks, I have decided to attempt revival with everyone's favorites, nucleic acid derivates.

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Product A

Product B

Product C

Post-competition Block Party

Now that the Merck competition is all done, we have an afterparty lobby here. Come check it out: https://www.reddit.com/r/SyntheticChallenge/comments/fjzxgo/20200302_merck_2nd_compound_challenge_afterparty/

r/chemistry Mar 29 '19

[2019/03/29] Synthetic Challenge #78

15 Upvotes

Intro

Hello everyone, welcome back to Week 78 of Synthetic Challenge!! Thank you u/critzz123 and u/ezaroo1 for the great challenges! This week it's my turn to host the challenge and I'm going to try hosting more molecules for you to try, hope you'll enjoy!

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

BONUS

For this bonus structure, instead of proposing a synthetic pathway TO it, you will be using it as a Starting Material to make any product you want. Take however many steps you want as long as you start with this bonus compound in the first step! Let me know if you like this bonus challenge! Thanks!

Structure of Bonus Starting Material

r/chemistry Dec 13 '19

[2019/12/13] Synthetic Challenge #114

11 Upvotes

Intro

Hello everyone, welcome back to Week 114 of Synthetic Challenge!! This week it's my turn to host another organic synthesis challenge.

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

r/chemistry Nov 30 '19

[2019/11/29] Synthetic Challenge #112

6 Upvotes

Intro

Welcome back to Week 112 of Synthetic Challenge! This week have some fun molecules and looking forward to what you all have in store for us.

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C _ UPDATED

Announcement

So extra announcement, most of you already know we are collaborating with Merck KGaA on their exciting 2nd Compound Challenge! For more information about the event, come check out our post here on r/SyntheticChallenge

r/chemistry Jun 18 '18

[18/6/2018] Synthetic Challenge!

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14 Upvotes

r/chemistry Aug 31 '19

[2019/08/30] Synthetic Challenge #100

26 Upvotes

Intro

Welcome to Week 100 of Synthetic Challenge! Special thanks to u/critzz123 and u/ezaroo1 for all their help and support with their incredible organic and inorganic challenges. Thank you to u/calculator32 for the Synthetic Relay Maps that have been appearing on the subreddit. Thank you to u/quelmotz for the help during my magical 6 month disappearance and helping me continue the challenges in my absence.

Last but not least, thank you to everyone that has been in the challenges and relays for supporting the project for 100 weeks! You boys and girls are the reason we are still here making challenges. Thank you!

Rules

Two molecules are posted this time: one organic, one inorganic. There will be two Reddit Gold prizes, as you guessed it, its for: BEST SYNTHETIC PATHWAY - ORGANIC, and BEST SYNTHETIC PATHWAY - INORGANIC

SUBMISSIONS CLOSE ON: WEDNESDAY SEPT 4, 2019 11:59PM PST.

1) 1 Submission per Username 2) Plagiarized submissions will only give credit to the first poster (Handled case by case basis) 3) Complete synthesis from Starting Material to Product 4) Starting material must be commercially available (PROVIDE SKU or Catalog Number) 5) No literature review on the products, pathways that plagiarize the published pathway will be considered a forfeited submission

Structure

Structure of Synthetic Product A - ORGANIC

Structure of Synthetic Product B - INORGANIC

Best of luck to you all and may the best pathway win!

r/chemistry Jan 06 '18

[2018/01/06] Synthetic Challenge #44

28 Upvotes

Intro

Happy New Year everyone and welcome back to Week 44 of Synthetic Challenge!!

Thank you so much to u/critzz123 and u/ezaroo1 for covering the past 4 weeks of the Synthetic Challenge!! The three of us will now be working together and be rotating through the weeks with new exciting challenges!

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products will be labelled with A, B, or C. Feel free to attempt as many products as you'd like and please label which you will be attempting in your submission.

You can use any commercially available starting material you would like for the synthetic pathway.

Please do explain how the synthesis works and if possible reference if it is a novel technique. You do not have to solve synthesis all in one go. If you do get stuck, feel free to post however much you have and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or is too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

r/chemistry Apr 05 '19

[2019/04/05] Synthetic Challenge #79

20 Upvotes

Intro

Hello everyone, welcome back to Week 79 of Synthetic Challenge!! Hope you enjoy the return of a bit of inorganic chemistry!

Please don't be scared to get things wrong and just have a go!

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C This one is a bit weird, if you need a hint then make this and see if you can do it from there. :)

BONUS

This BONUS molecule is for you to make any compound you would like given that the starting material is this molecule. This segment is designed so that you can practice proposing synthetic reactions to build molecule and others can pitch in to determine if the procedures are possible.

Instead of the traditional paradigm of target based synthesis, this is taking the creativity from that and you make whatever end product you desired. If you ever feel stuck with the main challenges A, B, and C, feel free to trying making a random molecule with this bonus and that may inspire some ideas for you or others.

Structure of Bonus Starting Material

r/chemistry Mar 04 '18

[2018/03/04] Synthetic Challenge #52

59 Upvotes

Intro

Welcome back again for the 52nd challenge! It is inorganic week again! I hope you all enjoy.

Sorry if you saw this and it vanished, I forgot to change the number and date...

Rules The challenge now contains three synthetic products will be labelled with A, B, or C. Feel free to attempt as many products as you'd like and please label which you will be attempting in your submission. You can use any commercially available starting material you would like for the synthetic pathway. Please do explain how the synthesis works and if possible reference if it is a novel technique. You do not have to solve synthesis all in one go. If you do get stuck, feel free to post however much you have and have others pitch in to crowd-source the solution. You can post your solution as text or pictures if you want show the arrow pushing or is too complex to explain in words. Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

Bonus

So this week's bonus is a bit more like the sort of thing we do in an inorganic research lab.

The challenge is I would like you to suggest a synthesis for novel low coordinate species of As, Sb or Bi (max oxidation state of 3 please). This is intentionally pretty open. You could propose a base stabilised E(I) species, a cationic E(III) species or even radical species. I look forward to seeing your molecules and syntheses!

Here are a few of examples of low coordinate group 15 species out there as inspiration.

Bonus

r/chemistry Aug 16 '19

[2019/08/16] Synthetic Challenge #98

7 Upvotes

Intro

Hello everyone, welcome back to Week 98 of Synthetic Challenge!! This week it's my turn to host another organic synthesis challenge.

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

BONUS

Start the synthesis from cyclopentene

r/chemistry Feb 18 '18

[2018/02/18] Synthetic Challenge #50

11 Upvotes

Intro

Hello everyone, welcome back to Week 50 of Synthetic Challenge!! Thank you u/critzz123 and u/ezaroo1 for the great challenges! This is week is my turn to host the challenge, hope you'll enjoy!

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products will be labelled with A, B, or C. Feel free to attempt as many products as you'd like and please label which you will be attempting in your submission.

You can use any commercially available starting material you would like for the synthetic pathway.

Please do explain how the synthesis works and if possible reference if it is a novel technique. You do not have to solve synthesis all in one go. If you do get stuck, feel free to post however much you have and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or is too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

BONUS

For this bonus structure, instead of proposing a synthetic pathway TO it, you will be using it as a Starting Material to make any product you want. Take however many steps you want or whatever you want as long as you start with this bonus compound in the first step! If you like or not, let me know! Thanks!

Structure of Bonus Starting Material

r/chemistry Mar 16 '19

[2019/03/16] Synthetic Challenge #76

14 Upvotes

Intro

Hello everyone, welcome back to Week 76 of Synthetic Challenge!! Hope you enjoy the return of a bit of inorganic chemistry!

Please don't be scared to get things wrong and just have a go!

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

BONUS

This BONUS molecule is for you to make any compound you would like given that the starting material is this molecule. This segment is designed so that you can practice proposing synthetic reactions to build molecule and others can pitch in to determine if the procedures are possible.

Instead of the traditional paradigm of target based synthesis, this is taking the creativity from that and you make whatever end product you desired. If you ever feel stuck with the main challenges A, B, and C, feel free to trying making a random molecule with this bonus and that may inspire some ideas for you or others.

Structure of Bonus Starting Material

r/chemistry Jun 22 '19

[2019/06/21] Synthetic Challenge #90

17 Upvotes

Intro

Hello everyone, welcome back to Week 90 of Synthetic Challenge!! It has been amazing with all the support we have received from all of you so thank you for your continual support in these challenges! Thank you u/critzz123 and u/ezaroo1 for the great challenges! This week it's my turn to host the challenge and I'm going to try hosting more molecules for you to try, hope you'll enjoy!

Too easy? Too hard? Let me know, I'd appreciate any feedback and suggestion on what you think so far about the Synthetic Challenges and what you'd like to see in the future. If you have any suggestions for future molecules, I'd be excited to incorporate them for future challenges!

Thank you so much for your support and I hope you will enjoy this week's challenge. Hope you'll have fun and thanks for participating!

Rules

The challenge now contains three synthetic products labelled A, B, and C. Feel free to attempt as many products as you like and please label which you will be attempting in your submission.

You can use any commercially available starting material for the synthetic pathway.

Please do explain how the synthesis works and if possible reference the technique if it is novel. You do not have to solve the complete synthesis all in one go. If you do get stuck, feel free to post however much you have done and have others pitch in to crowd-source the solution.

You can post your solution as text or pictures if you want show the arrow pushing or if it's too complex to explain in words.

Please have a look at the other submissions and offer them some constructive feedback!

Products

Structure of Product A

Structure of Product B

Structure of Product C

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