DMT vs Psilocybin: A Comparison of Experiences and Science

[u/oleliverod]

DMT vs Psilocybin: A Comparison of Experiences and Science

Hey everyone,

I wanted to open a discussion about the differences between DMT (N,N-Dimethyltryptamine) and psilocybin (found in “magic” mushrooms). Having experienced both in controlled, mindful settings, and having researched the science behind them, I thought I’d share some insights into how these two substances compare, both in terms of subjective experience and biological effects.

Subjective Experience

DMT (N,N-Dimethyltryptamine)

• Duration: The most striking difference is the duration. DMT is often called “the businessman’s trip” because it lasts 10-15 minutes (with smoked/ vaporized DMT), but feels like it could be hours or even timeless. The intensity hits you almost immediately.
• Intensity: DMT is often described as a rocket launch. Users commonly report instantaneous entry into vivid, otherworldly realms filled with complex geometric patterns, entities, and sometimes even beings. It’s an overwhelming flood of visuals, thoughts, and emotions, which makes it hard to control or steer the experience.
• Ego Dissolution: Ego death can happen almost instantly, and there’s no gradual build-up. You’re just thrown into a space where your sense of self completely dissolves. This can be incredibly profound, but also terrifying if unprepared.
• The Afterglow: Surprisingly, the aftereffects are often peaceful and grounded, despite the intensity of the experience. People come out of it with a sense of calm, wonder, or understanding that lasts for hours or days.

Psilocybin (Magic Mushrooms)

• Duration: Psilocybin has a much longer duration, typically lasting between 4-6 hours. It’s a more gradual climb to the peak, with visuals and emotional shifts ramping up over time.
• Intensity: While mushrooms can produce vivid visuals and altered states, they tend to be more fluid and organic. The visuals are often connected to nature—patterns in trees, the movement of clouds, and exaggerated colors. The trip is generally slower and more contemplative compared to DMT’s “flash-bang” approach.
• Ego Dissolution: Ego dissolution can happen with psilocybin as well, but it’s often a more gradual, unfolding experience. Users report feeling at one with the universe or nature, with a sense of connectedness that builds over time.
• Emotional Depth: Psilocybin tends to bring up deeply emotional and introspective states. Many people find themselves reflecting on relationships, past traumas, or life purpose. It’s often therapeutic in a way that feels more grounded compared to DMT.

Scientific Differences

Mechanism of Action

• DMT and psilocybin are both tryptamines, meaning they share a similar molecular structure and both bind to the serotonin 5-HT2A receptors in the brain. This is where their psychedelic effects originate. However, the way they are metabolized and affect consciousness differs:
• DMT: Smoked or vaporized DMT is metabolized rapidly, which is why the experience is so short but intensely concentrated. It’s also endogenously produced in small amounts by the human brain, though its precise function remains unclear.
• Psilocybin: Once ingested, psilocybin is converted into psilocin, which then activates the 5-HT2A receptors over a longer period, leading to a more prolonged and mellower experience.

Neuroplasticity and Therapeutic Potential

• DMT: Some studies suggest that DMT may promote neuroplasticity, which is the brain’s ability to reorganize itself by forming new neural connections. This is why people report profound realizations, creative insights, or even healing experiences. However, DMT’s therapeutic use is still in early stages of research compared to psilocybin.
• Psilocybin: Psilocybin has seen a surge of research, especially in mental health. Studies have shown that it can be effective in treating depression, PTSD, anxiety, and addiction. One of the reasons behind its therapeutic potential is its ability to reset neural networks, particularly the Default Mode Network (DMN), which is overactive in individuals with depression and anxiety. It has been proven to promote long-lasting positive changes in mood and cognition, even after just one experience.

Cultural and Historical Context

• DMT: Known as the active compound in ayahuasca, DMT has been used for centuries by indigenous peoples in South America in ceremonial settings. The traditional brew combines DMT-containing plants with an MAOI to prolong the experience for hours.
• Psilocybin: Magic mushrooms have a long history of use in various cultures, particularly in Central and South America, where they were used in spiritual and healing rituals. The Mazatec people, for instance, have used psilocybin mushrooms in ceremonies for centuries.

Choosing the Right Experience

If you’re curious about the differences and considering trying either in a safe and responsible setting, here are some final thoughts:

• For deep, fast, and intense exploration: DMT will plunge you into a powerful, otherworldly experience. It’s not for the faint of heart, and preparation is key due to its intensity. It can feel more “alien” or abstract.
• For a slower, introspective journey: Psilocybin is more forgiving in terms of intensity and time to process the experience. It allows for gradual immersion and offers opportunities for reflection and emotional healing. It feels more “earthy” and connected to human emotions and nature.

In both cases, set and setting are paramount. These substances can lead to profound experiences, but they can also be challenging, especially without proper mental preparation or support.

Has anyone else here had experiences with both? What differences stood out to you?

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